📋Overview
This deficiency leads to the uncontrolled activation of biochemical pathways within the immune and contact systems, resulting in fluid leakage from blood vessels into nearby tissues. This physiological process manifests as localized swelling, often referred to as angioedema, which can affect various parts of the body including the limbs, face, and intestinal tract.
The condition is primarily classified as hereditary angioedema when caused by inherited genetic mutations, although it may also manifest as an acquired disorder in some individuals. Unlike common allergic reactions, the swelling associated with this protein deficiency typically occurs without the presence of hives or itching.
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